Photodynamic Diagnosis of Hematoporphyrin Derivative and Laser
نویسندگان
چکیده
منابع مشابه
Pharmacological modulation of photodynamic therapy with hematoporphyrin derivative and light.
The interactions between photodynamic therapy (PDT) with hemotoporphyrin derivative (HPD) and treatment with cytotoxic drugs have been examined using both an in vitro tissue culture assay and an in vivo transplantable mouse tumor assay. Adriamycin (0.5-4.0 mg/kg) administered with HPD and at the time of irradiation potentiated the photodynamic effect, doubling the duration of tumor control. Adr...
متن کاملIn vitro and in vivo light dose rate effects related to hematoporphyrin derivative photodynamic therapy.
In vitro and in vivo experiments were performed to evaluate the parameter of light dose rate as it relates to the efficiency of hematoporphyrin derivative (HPD)-induced photosensitization. Exponentially growing Chinese hamster ovary cells were incubated with HPD (25 micrograms/ml) and were then exposed to red light (630 nm) delivered at different dose rates. A total of five dose rates (0.5, 5.0...
متن کاملHistological study of the effect of hematoporphyrin derivative photodynamic therapy on the rat jejunum.
Hematoporphyrin derivative photodynamic therapy is evolving as a local treatment for neoplastic disease. The emphasis of previous research has been on the determination of mechanisms of tumoricidal activity and defining the tumoricidal porphyrin component in hematoporphyrin derivative. The effect of hematoporphyrin derivative photodynamic therapy on normal tissue has received little attention. ...
متن کاملExpression of potentially lethal damage in Chinese hamster cells exposed to hematoporphyrin derivative photodynamic therapy.
Experiments were performed to determine whether the expression and/or repair of potentially lethal damage could be observed in mammalian cells exposed to hemataporphyrin derivative (HPD) photodynamic therapy (PDT). Photodynamic therapy was combined with posttreatment protocols known to inhibit the repair of potentially lethal damage in cells treated with X-rays, ultraviolet radiation, or alkyla...
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ژورنال
عنوان ژورنال: THE JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE
سال: 1990
ISSN: 0288-6200
DOI: 10.2530/jslsm1980.11.2_51